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                                <h1>The Defeat Parkinson’s Platform Tübingen</h1>
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                                    <p>
                                        Supported by a major private donation and research grants from the
                                        Michael J. Fox Foundation (MJFF) and EU worth more than 2,5 Million Euro,
                                        the Hertie-Institute for Clinical Brain Research and the German Center
                                        for Neurodegenerative diseases (DZNE) in Tübingen have established the
                                        Defeat Parkinson’s Research Platform. Clinical and pre-clinical researchers
                                        will be joining forces to use cutting edge molecular, genetic,
                                        cell biologic and computational technologies to better understand
                                        the complex mechanisms underlying the disorder and to develop novel
                                        biomarkers and treatments.
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                                        Source: HPE
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                                    <p>
                                        Parkinson’s disease (PD) is one of the most devastating neurodegenerative conditions.
                                        Although dopamine replacement treatment or deep brain stimulation can give
                                        remarkable temporary benefit to many patients, there is still no cure and
                                        it is not yet possible to significantly slow the progression of the disease.
                                        However, in recent years we have seen a remarkable progress in the understanding
                                        of the genetic, molecular and cellular underpinnings of the disorder,
                                        and new treatments may be within reach in the not too distant future.
                                    </p>
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                                <!-- Text-Image with Teaser - Element final START -->
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                                    <h2>Mission statement</h2>
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                                                    Corona-Forschung in Bonn: Rheinland Studie startet groß angelegten Bluttest
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                                                    Interview mit Prof. Gasser zum Welt-Parkinson-Tag
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                                                    Immunzellen gegen Alzheimer?
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                                        In the Defeat Parkinson’s Research Platform we will work together
                                        in an interdisciplinary team to explore how genetic variability leads
                                        to alterations in cellular and molecular processes that define disease
                                        risk and progression. To achieve this goal, we will join forces with
                                        our international collaborators (<a href="http://pdgenetics.org/">http://pdgenetics.org/</a>)
                                        to investigate the entire genomic variation in large groups of affected and at-risk individuals
                                        with next-generation sequencing technologies and correlate this data with transcriptome
                                        and epigenome information to build gene expression models. We will then explore how these
                                        changes alter cellular processes by high content/high throughput analysis,
                                        even at the single cell level, use novel computational approaches to integrate these
                                        findings in complex models. With our expert knowledge on disease modeling in induced
                                        pluripotent stem cells (iPSc) and animal models we will then investigate selected
                                        genes in depth and bring our knowledge back to our patients to discover and validate
                                        novel biomarkers and treatments.
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                                                DZNE-Stiftung für Forschung und Innovation im Stifterverband für die Deutsche Wissenschaft e.V.
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                                            Nächster Termin: 23.06.2020
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